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DC Field | Value | Language |
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dc.contributor.author | Onyegbula ·, K. | - |
dc.contributor.author | Onile ·, O.S. | - |
dc.contributor.author | Okoje ·, V.N. | - |
dc.contributor.author | Anumudu, C.I. | - |
dc.date.accessioned | 2021-05-28T13:38:24Z | - |
dc.date.available | 2021-05-28T13:38:24Z | - |
dc.date.issued | 2014-06 | - |
dc.identifier.uri | DOI 10.1007/s12558-014-0340-y | - |
dc.identifier.uri | http://repository.elizadeuniversity.edu.ng/jspui/handle/20.500.12398/1064 | - |
dc.description | Staff Publication | en_US |
dc.description.abstract | This study investigated the presence or absence of β-catenin and Patched1 (PTCH1) genes involved in the developmental pathway in ameloblastoma, in order to clarify the genetic etiology of this tumor. Aim: The aim of this study was to investigate whether PTCH1 and β-catenin genes are involved in the development of ameloblastoma. Subjects and Methods: Archived formalin-fixed paraffinembedded specimens of 89 ameloblastoma cases from the year 2000 to 2010 were genotyped by polymerase chain reaction (PCR). Results: A total of 21 (23.6%) of the 89 ameloblastoma cases were positive for β-catenin gene, where 14/21 (66.7%) cases were mandibular ameloblastoma. Plexiform 5/21 (23.8%) and cystic 5/21 (23.8%) ameloblastoma were the most regular histological type positive for β-catenin. However, β-catenin positive was more in the feminine gender (11/19, 57.9%) than the masculine (8/19, 42.1%). Only one case was positive for PTCH1 gene and this was histologically a mandibular site and plexiform-type ameloblastoma. Conclusions: This study suggested that β-catenin and PTCH1 genes may play an important role in the pathogenesis of ameloblastoma | en_US |
dc.language.iso | en | en_US |
dc.publisher | Journal of African Cancer | en_US |
dc.subject | Ameloblastoma · | en_US |
dc.subject | β-catenin · | en_US |
dc.subject | Odontogenic · | en_US |
dc.subject | Patche | en_US |
dc.title | Developmental Signaling Genes in Ameloblastoma | en_US |
dc.type | Article | en_US |
Appears in Collections: | Research Articles |
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File | Description | Size | Format | |
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sprjac000331.pdf | 472.78 kB | Adobe PDF | View/Open |
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