Ficus asperifolia Miq-enriched biscuit diet protects against L-NAME induced hyperlipidemia and hypertension in rats
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Date
2021-06
Journal Title
Journal ISSN
Volume Title
Publisher
Food Frontiers
Abstract
Dietary sources of functional foods and nutraceutical have shown strong potentials in
the management of hypertension and its complications. Sandpaper leaves, Ficus asperifolia
Miq (FA), particularly found in Africa has a rich folkloric history in the management
of diabetes and hypertension. This study produced biscuits supplemented with
blends of FA at 2.5% and 5% fed to Nw (G)-nitro-L-arginine-methyl-ester (L-NAME,
40 mg/kg/day) induced-hypertensive rats for 14 days followed by the assessment of
blood pressure, lipid profile, and atherogenic index in hypertensive rats. The phenolic
constituents of FA blends were analyzed using high-performance liquid chromatography
diode-anode (HPLC-DAD). Thereafter, the mean arterial blood pressure (MABP)
and systolic blood pressure (SBP) was measured using the tail-cuff method afterwhich
the heart and lungs of ratswere collected, weighed, and the antioxidant status and lipid
cholesterol profile were assessed. We realized that recorded phenolic constituents
in extracts of FA was at a high level and FA enriched biscuit-diet caused a significant
decrease in SBP and MABP in L-NAME-induced hypertensive rats, body weight,
atherogenic index and cholesterol profile in treated rats. However, FA enriched biscuit
resulted in increased activities of catalase (CAT), superoxide dismutase (SOD), and
glutathione-S-transferase (GST) antioxidant enzymes in the heart and lungs of hypertensive
rats. This study revealed that FA enriched biscuit-diet does not only have antihypertensive
and antioxidant potential in L-NAME-induced hypertensive rats but also
plays a protective role in themanagement of hyperlipidemia.
Description
Staff Publication
Keywords
anti-hyperlipidemia,, antihypertensive,, Ficus asperifolia Miq (FA),, HPLC-DAD,, N(G)-nitro-Larginine- methyl-ester (L-NAME)