Prostaglandin levels and semen quality in male partners of infertile couples in Ile-Ife, Nigeria

Abstract

The study revealed a high percentage of men with sub-normal semen .Range of PGF2á in the subjects was 0.15-11.05µg/ml with a mean of 2.77± 0.23 µg/ml while that of PGE was 21.8- 652.0 µg/ml with a mean of 248.79± 13.88 µg/ml. Among men with normal semen profile, mean PGF2á and PGE levels are 2.1± 0.32 µg/ml and 325.1± 28.3 µg/ml respectively while that in semen of men with subnormal semen are 3.0± 0.28 µg/ml and 225.1 ± 15.1µg/ml respectively. Despite the wide range of PG values in all the groups, significant differences(P<0.05) were found to exist between the PG values of men in the normal and sub normal semen groups. Significant differences were also found when they were grouped according to sperm count alone. However, differences observed when in the grouping according to other individual semen characteristics are not significant. Conclusion: The wide range of PG values obtained in all the groups make it difficult to make far reaching conclusions as to the relationship between PG levels and semen quality. Further research is desirable in establishing the role of PGs in sperm function.