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DC Field | Value | Language |
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dc.contributor.author | Adefegha, Stephen A. | - |
dc.contributor.author | Omojokun, Olasunkanmi S. | - |
dc.contributor.author | Oboh, Ganiyu | - |
dc.contributor.author | Fasakin, Olasunkanmi | - |
dc.contributor.author | Ogunsuyi, Opeyemi | - |
dc.date.accessioned | 2021-02-09T10:23:37Z | - |
dc.date.available | 2021-02-09T10:23:37Z | - |
dc.date.issued | 2015-11-16 | - |
dc.identifier.citation | Adefegha, S. A., Omojokun, O. S., Oboh, G., Fasakin, O., & Ogunsuyi, O. (2016). Modulatory Effects of Ferulic Acid on Cadmium-Induced Brain Damage. Journal of Evidence-Based Complementary & Alternative Medicine, 21(4), NP56–NP61. doi:10.1177/2156587215621726 | en_US |
dc.identifier.uri | DOI: 10.1177/2156587215621726 | - |
dc.identifier.uri | http://repository.elizadeuniversity.edu.ng/jspui/handle/20.500.12398/822 | - |
dc.description | Staff Publication | en_US |
dc.description.abstract | Studies have shown the pharmacological relevance of phenolics like ferulic acid (FA) in promoting health. This study sought to investigate the modulatory effects of FA on cadmium-induced brain damage in rats. Brain damage was induced in Wistar strain rats by oral administration of cadmium (5 mg/kg body weight) for 21 days. Assays for malondialdehyde (MDA) content, acetylcholinesterase (AChE), butyrylcholinesterase (BChE), monoamine oxidase (MAO), and Naþ/Kþ-ATPase activities were carried out. The study revealed significant (P < .05) increases in the MDA content and all enzymes’ (AChE, BChE, MAO, and Naþ/Kþ- ATPase) activity investigated following cadmium administration. However, rats administered FA (10 and 20 mg/kg body weight) alongside cadmium significantly (P < .05) protected the brain by reversing the level of lipid peroxidation as measured by the MDA content as well as the enzymes’ activity. This study, therefore, substantiates the neuroprotective potentials of FA especially in the management of cadmium-induced toxicity. | en_US |
dc.language.iso | en | en_US |
dc.publisher | SAGE | en_US |
dc.subject | Cadmium, | en_US |
dc.subject | Ferulic acid, | en_US |
dc.subject | Cholinesterases | en_US |
dc.subject | Monoamine oxidase, | en_US |
dc.subject | Naþ/Kþ-ATPase, | en_US |
dc.subject | Malondialdehyde | en_US |
dc.title | Modulatory Effects of Ferulic Acid on Cadmium-Induced Brain Damage | en_US |
dc.type | Article | en_US |
Appears in Collections: | Research Articles |
Files in This Item:
File | Description | Size | Format | |
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2156587215621726.pdf | 276.59 kB | Adobe PDF | View/Open |
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