Please use this identifier to cite or link to this item:
http://repository.elizadeuniversity.edu.ng/jspui/handle/20.500.12398/1033
Title: | Designing a conserved peptide‑based subunit vaccine against SARS‑CoV‑2 using immunoinformatics approach |
Authors: | Oladipo, Elijah Kolawole Ajayi, Ayodeji Folorunsho Onile, O.S. Ariyo, Olumuyiwa Elijah Jimah, Esther Moradeyo Ezediuno, Louis Odinakaose |
Keywords: | SARsCoV-2 · Vaccine · Immunoinformatics · Adjuvants · Non-allergic · Epitopes |
Issue Date: | 6-Jan-2021 |
Publisher: | In Silico Pharmacology |
Abstract: | The widespread of coronavirus (COVID-19) is a new global health crisis that poses a threat to the world. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) originated in bats and was discovered first in Wuhan, Hubei province, China in December 2019. Immunoinformatics and bioinformatics tools were employed for the construction of a multi-epitope subunit vaccine to prevent the diseases. The antigenicity, toxicity and allergenicity of all epitopes used in the construction of the vaccine were predicted and then conjugated with adjuvants and linkers. Vaccine Toll-Like Receptors (2, 3, 4, 8 and 9) complex was also evaluated. The vaccine construct was antigenic, non-toxic and non-allergic, which indicates the vaccines ability to induce antibodies in the host, making it an effective vaccine candidate. |
Description: | Staff Publication |
URI: | https://doi.org/10.1007/s40203-020-00062-x http://repository.elizadeuniversity.edu.ng/jspui/handle/20.500.12398/1033 |
Appears in Collections: | Research Articles |
Files in This Item:
File | Description | Size | Format | |
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Oladipo2021_Article_DesigningAConservedPeptide-bas.pdf | 8.68 MB | Adobe PDF | View/Open |
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