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|Title:||Effect of co-administration of Green Tea (Camellia sinensis) on Clove- (Syzygium Aromaticum) Induced Hepatotoxicity and Oxidative Stress in Wistar Rats|
|Authors:||Adeyemi, Joseph A.|
Olawuyi, Solomon T.
Bamidele, Olufemi Samuel
Adedire, Chris O.
|Publisher:||Indian Journal of Physiology and Pharmacology|
|Abstract:||The study was designed to investigate the potential of oil extracts of clove (Syzygium aromaticum) to induce oxidative stress and hepatotoxicity in Wistar rats. The ameliorative effect due to co-administration with green tea, Camellia sinensis was also determined. Adult Wistar rats were exposed via oral gavage to one of the following: mineral oil (negative control), 5% green tea (GT), 12.5 mg/kg/day chlorpyrifos (CHL, positive control), 360 mg/kg/day clove oil (CO), green tea + chlorpyrifos (GT + CHL) and green tea + clove oil (GT + CO). Experimental treatment lasted three weeks, after which the animals were sacrificed and the following indices of oxidative stress and hepatotoxicity were determined in the plasma: levels of reduced glutathione (GSH), activities of catalase, glutathione peroxidase (GPx), aspartate amino transferase (AST), alanine amino transferase (ALT), and alkaline phosphatase (ALP). There was a significant decrease in plasma levels of GSH in the chlorpyrifos and S. aromaticum treated groups compared to the control rats. The activities of AST and ALT were higher in the chlorpyrifos and S. aromaticum treated groups compared to the control, however these data were only significant in the chlorpyrifos treated group. The activities of GPx, catalase and ALP did not differ significantly among the groups. The co-administration with C. sinensis resulted in less depletion of GSH as well as reduced levels of plasma AST and ALT. Overall, the results of this study show that the co-administration with C. sinensis has the potential to ameliorate the clove- induced oxidative stress and hepatotoxicity in rats.|
|Appears in Collections:||Research Articles|
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