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Title: A global metagenomic map of urban microbiomes and antimicrobial resistance
Authors: Osuolale, Olayinka O.
Danko, David
Bezdan, Daniela
et al
Keywords: metagenomic
antimicrobial resistance
Issue Date: 26-May-2021
Publisher: Cell Journal by Elsevier
Citation: Danko, D., Bezdan, D., Afshin, E. E., Ahsanuddin, S., Bhattacharya, C., Butler, D. J., … Jackson, K. (2021). A global metagenomic map of urban microbiomes and antimicrobial resistance. Cell, 184(13), 3376–3393.e17. doi:10.1016/j.cell.2021.05.002
Abstract: We present a global atlas of 4,728 metagenomic samples from mass-transit systems in 60 cities over 3 years, representing the first systematic, worldwide catalog of the urban microbial ecosystem. This atlas provides an annotated, geospatial profile of microbial strains, functional characteristics, antimicrobial resistance (AMR) markers, and genetic elements, including 10,928 viruses, 1,302 bacteria, 2 archaea, and 838,532 CRISPR arrays not found in reference databases. We identified 4,246 known species of urban microorganisms and a consistent set of 31 species found in 97% of samples that were distinct from human commensal organisms. Profiles of AMR genes varied widely in type and density across cities. Cities showed distinct microbial taxonomic signatures that were driven by climate and geographic differences. These results constitute a highresolution global metagenomic atlas that enables discovery of organisms and genes, highlights potential public health and forensic applications, and provides a culture-independent view of AMR burden in cities.
Description: Staff Publication
Appears in Collections:Research Articles

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