Designing a conserved peptide‑based subunit vaccine against SARS‑CoV‑2 using immunoinformatics approach
Loading...
Date
2021-01-06
Journal Title
Journal ISSN
Volume Title
Publisher
In Silico Pharmacology
Abstract
The widespread of coronavirus (COVID-19) is a new global health crisis that poses a threat to the world. The severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) originated in bats and was discovered first in Wuhan, Hubei province,
China in December 2019. Immunoinformatics and bioinformatics tools were employed for the construction of a multi-epitope
subunit vaccine to prevent the diseases. The antigenicity, toxicity and allergenicity of all epitopes used in the construction
of the vaccine were predicted and then conjugated with adjuvants and linkers. Vaccine Toll-Like Receptors (2, 3, 4, 8 and 9)
complex was also evaluated. The vaccine construct was antigenic, non-toxic and non-allergic, which indicates the vaccines
ability to induce antibodies in the host, making it an effective vaccine candidate.
Description
Staff Publication
Keywords
SARsCoV-2 ·, Vaccine ·, Immunoinformatics ·, Adjuvants ·, Non-allergic ·, Epitopes