Relationship between Physico-chemical Parameters and Phylogenetics Study of Human Low Density Lipoprotein Receptor-Related Protein (LRP)
Loading...
Date
2014-02-12
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
SCIENCEDOMAIN
Abstract
In this study, 11members of human low density lipoprotein receptor-related protein (LRP)
sequences was retrieved from UniProtKB/ SWISS-PROT protein database and was
analyzed for information about their structural, functional and phylogenetic features. This
was achieved by using many established biocomputational tools which was available at
their latest version. This study shows that LRP 12 and 3 are closely related with LRP8
being their nearest neighbor. In all, it was observed that there were very low possession
of certain essential amino acid like glycine, proline and a very high aliphatic in all the LRP
family. Considering the evolutionary history, functional domains, high aliphatic index,
overall proportion of glycine and proline and the established role of one (LRP8) of this
closely related LRP in diseases, it is thus predicted that the other closely related LRP3
and 12 molecules may be important candidate in investigating the aetiopathology of
Myocardial infarction1diseases or other heart related disorder.
Description
Keywords
Low density lipoprotein receptor-related protein (LRP), biocomputational tools, domains, phylogenetics