Effects of drying on cholinesterases and angiotensin-I converting enzyme inhibitory potential and phenolic constituents of African mistletoe (Loranthus bengwensis L) leaves from kolanut host tree
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Date
2017-12-15
Journal Title
Journal ISSN
Volume Title
Publisher
Wiley
Abstract
This study investigated the most appropriate drying method (sun drying, oven drying, and shade
drying) for mistletoe leaves obtained from kolanut tree. The phenolic constituents were characterized
using high performance liquid chromatography–diode array detector, while the inhibitory
effect of the aqueous extracts of the leaves on cholinesterases and angiotensin-I converting
enzyme (ACE) and antioxidant activities were determined in vitro. The extracts inhibited acetylcholinesterase
(AChE), butyrylcholinesterase (BChE), and ACE in dose-dependent manner. However,
extract from sun-dried sample exhibited the highest AChE, BChE, and ACE inhibitory effect while
extract from shade-dried sample had the least. Likewise, sun-dried sample exhibited the highest
antioxidant properties as exemplified by Fe21-chelating, 1,1-diphenyl-2 picrylhdrazyl, OH, and
nitric oxide radical scavenging abilities. This study also revealed the presence of 20 phenolic compounds
with caffeic acid being the most predominant. Conclusively, kolanut host tree mistletoe
leaves can be used as therapeutic agent in the management of Alzheimer’s disease and
hypertension.
Description
Staff Publication
Keywords
Angiotensin-I converting enzyme,, Cholinesterase,, Drying,, Kolanut,, Mistletoe,, Phenolics
Citation
Omojokun, O. S., Oboh, G., & Ademiluyi, A. O. (2018). Effects of drying on cholinesterases and angiotensin-I converting enzyme inhibitory potential and phenolic constituents of African mistletoe (Loranthus bengwensis L ) leaves from kolanut host tree. Journal of Food Biochemistry, 42(4), e12510. doi:10.1111/jfbc.12510