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Title: Modulatory Effects of Ferulic Acid on Cadmium-Induced Brain Damage
Authors: Adefegha, Stephen A.
Omojokun, Olasunkanmi S.
Oboh, Ganiyu
Fasakin, Olasunkanmi
Ogunsuyi, Opeyemi
Keywords: Cadmium,
Ferulic acid,
Monoamine oxidase,
Issue Date: 16-Nov-2015
Publisher: SAGE
Citation: Adefegha, S. A., Omojokun, O. S., Oboh, G., Fasakin, O., & Ogunsuyi, O. (2016). Modulatory Effects of Ferulic Acid on Cadmium-Induced Brain Damage. Journal of Evidence-Based Complementary & Alternative Medicine, 21(4), NP56–NP61. doi:10.1177/2156587215621726
Abstract: Studies have shown the pharmacological relevance of phenolics like ferulic acid (FA) in promoting health. This study sought to investigate the modulatory effects of FA on cadmium-induced brain damage in rats. Brain damage was induced in Wistar strain rats by oral administration of cadmium (5 mg/kg body weight) for 21 days. Assays for malondialdehyde (MDA) content, acetylcholinesterase (AChE), butyrylcholinesterase (BChE), monoamine oxidase (MAO), and Naþ/Kþ-ATPase activities were carried out. The study revealed significant (P < .05) increases in the MDA content and all enzymes’ (AChE, BChE, MAO, and Naþ/Kþ- ATPase) activity investigated following cadmium administration. However, rats administered FA (10 and 20 mg/kg body weight) alongside cadmium significantly (P < .05) protected the brain by reversing the level of lipid peroxidation as measured by the MDA content as well as the enzymes’ activity. This study, therefore, substantiates the neuroprotective potentials of FA especially in the management of cadmium-induced toxicity.
Description: Staff Publication
URI: DOI: 10.1177/2156587215621726
Appears in Collections:Research Articles

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