Modulatory Effects of Ferulic Acid on Cadmium-Induced Brain Damage
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Date
2015-11-16
Journal Title
Journal ISSN
Volume Title
Publisher
SAGE
Abstract
Studies have shown the pharmacological relevance of phenolics like ferulic acid (FA) in promoting health. This study sought to
investigate the modulatory effects of FA on cadmium-induced brain damage in rats. Brain damage was induced in Wistar strain rats
by oral administration of cadmium (5 mg/kg body weight) for 21 days. Assays for malondialdehyde (MDA) content, acetylcholinesterase
(AChE), butyrylcholinesterase (BChE), monoamine oxidase (MAO), and Naþ/Kþ-ATPase activities were carried
out. The study revealed significant (P < .05) increases in the MDA content and all enzymes’ (AChE, BChE, MAO, and Naþ/Kþ-
ATPase) activity investigated following cadmium administration. However, rats administered FA (10 and 20 mg/kg body weight)
alongside cadmium significantly (P < .05) protected the brain by reversing the level of lipid peroxidation as measured by the MDA
content as well as the enzymes’ activity. This study, therefore, substantiates the neuroprotective potentials of FA especially in the
management of cadmium-induced toxicity.
Description
Staff Publication
Keywords
Cadmium,, Ferulic acid,, Cholinesterases, Monoamine oxidase,, Naþ/Kþ-ATPase,, Malondialdehyde
Citation
Adefegha, S. A., Omojokun, O. S., Oboh, G., Fasakin, O., & Ogunsuyi, O. (2016). Modulatory Effects of Ferulic Acid on Cadmium-Induced Brain Damage. Journal of Evidence-Based Complementary & Alternative Medicine, 21(4), NP56–NP61. doi:10.1177/2156587215621726