Browsing by Author "Adeyemi, Joseph A."

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    Effect of co-administration of Green Tea (Camellia sinensis) on Clove- (Syzygium Aromaticum) Induced Hepatotoxicity and Oxidative Stress in Wistar Rats
    (Indian Journal of Physiology and Pharmacology, 2018-04) Adeyemi, Joseph A.; Arowolo, O.K.; Olawuyi, Solomon T.; Alegbeleye, Daniel; Ogunleye, Aderopo; Bamidele, Olufemi Samuel; Adedire, Chris O.
    The study was designed to investigate the potential of oil extracts of clove (Syzygium aromaticum) to induce oxidative stress and hepatotoxicity in Wistar rats. The ameliorative effect due to co-administration with green tea, Camellia sinensis was also determined. Adult Wistar rats were exposed via oral gavage to one of the following: mineral oil (negative control), 5% green tea (GT), 12.5 mg/kg/day chlorpyrifos (CHL, positive control), 360 mg/kg/day clove oil (CO), green tea + chlorpyrifos (GT + CHL) and green tea + clove oil (GT + CO). Experimental treatment lasted three weeks, after which the animals were sacrificed and the following indices of oxidative stress and hepatotoxicity were determined in the plasma: levels of reduced glutathione (GSH), activities of catalase, glutathione peroxidase (GPx), aspartate amino transferase (AST), alanine amino transferase (ALT), and alkaline phosphatase (ALP). There was a significant decrease in plasma levels of GSH in the chlorpyrifos and S. aromaticum treated groups compared to the control rats. The activities of AST and ALT were higher in the chlorpyrifos and S. aromaticum treated groups compared to the control, however these data were only significant in the chlorpyrifos treated group. The activities of GPx, catalase and ALP did not differ significantly among the groups. The co-administration with C. sinensis resulted in less depletion of GSH as well as reduced levels of plasma AST and ALT. Overall, the results of this study show that the co-administration with C. sinensis has the potential to ameliorate the clove- induced oxidative stress and hepatotoxicity in rats.
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    Pesticides-induced Cardiovascular Dysfunctions: Prevalence and Associated Mechanisms
    (Bentham Science Publisher : Current Hypertension Reviews, 2021) Adeyemi, Joseph A.; Ukwenya, Victor O.; Arowolo, O.K.; Olise, Christian C.
    Increased applications of pesticides, mainly in agriculture and public health, have resulted in increased chances of human exposure to pesticides. Chronic exposure to pesticides has been implicated in several human diseases, including cardiovascular diseases. Cardiovascular diseases are broadly used for various heart pathological conditions, including a defect in blood vessels, and they include myocardial infarction, atherosclerosis, stroke, cardiomyopathy, coronary heart disease, etc. In this review, the association between human exposure to pesticides and the development of cardiovascular diseases was discussed using epidemiological and laboratory data. The toxicokinetics of pesticides in humans was reviewed, as well as the risk factors for cardiovascular diseases. The important role of oxidative stress principally the induction of reactive oxygen species as the signaling molecules for various signaling pathways involved in pesticides-induced cardiovascular disease, was discussed.