Browsing by Author "Arowolo, O.K."

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    Effect of co-administration of Green Tea (Camellia sinensis) on Clove- (Syzygium Aromaticum) Induced Hepatotoxicity and Oxidative Stress in Wistar Rats
    (Indian Journal of Physiology and Pharmacology, 2018-04) Adeyemi, Joseph A.; Arowolo, O.K.; Olawuyi, Solomon T.; Alegbeleye, Daniel; Ogunleye, Aderopo; Bamidele, Olufemi Samuel; Adedire, Chris O.
    The study was designed to investigate the potential of oil extracts of clove (Syzygium aromaticum) to induce oxidative stress and hepatotoxicity in Wistar rats. The ameliorative effect due to co-administration with green tea, Camellia sinensis was also determined. Adult Wistar rats were exposed via oral gavage to one of the following: mineral oil (negative control), 5% green tea (GT), 12.5 mg/kg/day chlorpyrifos (CHL, positive control), 360 mg/kg/day clove oil (CO), green tea + chlorpyrifos (GT + CHL) and green tea + clove oil (GT + CO). Experimental treatment lasted three weeks, after which the animals were sacrificed and the following indices of oxidative stress and hepatotoxicity were determined in the plasma: levels of reduced glutathione (GSH), activities of catalase, glutathione peroxidase (GPx), aspartate amino transferase (AST), alanine amino transferase (ALT), and alkaline phosphatase (ALP). There was a significant decrease in plasma levels of GSH in the chlorpyrifos and S. aromaticum treated groups compared to the control rats. The activities of AST and ALT were higher in the chlorpyrifos and S. aromaticum treated groups compared to the control, however these data were only significant in the chlorpyrifos treated group. The activities of GPx, catalase and ALP did not differ significantly among the groups. The co-administration with C. sinensis resulted in less depletion of GSH as well as reduced levels of plasma AST and ALT. Overall, the results of this study show that the co-administration with C. sinensis has the potential to ameliorate the clove- induced oxidative stress and hepatotoxicity in rats.
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    Pesticides-induced Cardiovascular Dysfunctions: Prevalence and Associated Mechanisms
    (Bentham Science Publisher : Current Hypertension Reviews, 2021) Adeyemi, Joseph A.; Ukwenya, Victor O.; Arowolo, O.K.; Olise, Christian C.
    Increased applications of pesticides, mainly in agriculture and public health, have resulted in increased chances of human exposure to pesticides. Chronic exposure to pesticides has been implicated in several human diseases, including cardiovascular diseases. Cardiovascular diseases are broadly used for various heart pathological conditions, including a defect in blood vessels, and they include myocardial infarction, atherosclerosis, stroke, cardiomyopathy, coronary heart disease, etc. In this review, the association between human exposure to pesticides and the development of cardiovascular diseases was discussed using epidemiological and laboratory data. The toxicokinetics of pesticides in humans was reviewed, as well as the risk factors for cardiovascular diseases. The important role of oxidative stress principally the induction of reactive oxygen species as the signaling molecules for various signaling pathways involved in pesticides-induced cardiovascular disease, was discussed.
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    POTENTIAL METAL TOXICITY OF SOME HERBAL PLANTS USED IN THE TREATMENT OF MALARIA IN ONDO STATE, NIGERIA
    (European Journal of Advanced Research in Biological and Life Sciences, 2019-12-31) Bada, Adeola A.; Lawal, S.A.; Arowolo, O.K.; Olabode, K.O.
    Unorthodox medical practice involving the use of herbal plants and other biological specimens, though permissible, is growing unabated in many less developed Nations of the world due to poverty and lack of healthcare facilities without regard to the potential threat/ toxicity from the consumption of these alternative medicines. Thirteen (13) herbal plants commonly used for the treatment of malaria in Ondo state, Nigeria were selected for the study and evaluated for their heavy metal content viz: Cadmium, Zinc, Lead and Chromium using Atomic Absorption Spectrophotometer (AAS).The result showed increased cadmium concentration in the range of 0.014-0.077mg/kg with 76.9% of the selected plants having cadmium concentrations above the permissible limit. Zinc being an essential micro nutrient varied in the range of 0.304-1.539 mg/kg with 100% of the plants within the permissible limits for herbal plants. The lead concentration is within the permissible limit for all the selected plants and in the range of 0.141-0.464mg/kg. Chromium being a trace metal and of toxic potential was detected in 38.46% of the selected plants within the permissible limit and in the range of 0.002-0.356mg/kg. Mangifera indica leaves has chromium concentration of 0.180mg/kg but was not detected in the bark which might be due to anthropogenic influences and gaseous exchange in the leaves. The zinc, lead and chromium levels of these herbs were good for consumption, but cadmium level need to be adjusted to prevent kidney failure during consumption.
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    TREATABILITY STUDIES ON RAW WATER FROM APONMU RESERVIOR IN ILARA – MOKIN, , NIGERIA
    (Proceedings of the OAU Faculty of Technology Conference 2019, 2019) Oke;, I.A.; Daramola, D.A.; Adeniji, A.A.; Fakorede, E.O.; Adanikin, Ariyo; Olabode, K.O.; Aladeyelu, A.; Arowolo, O.K.; Agada, O.V.; Agboola, A.; Gabriel, O.
    Adequate water supply is an important ingredient in human’s development. In this study, samples of war water were collected from Aponmu reservoir at Elizade University, Ilara – Mokin , Ondo State, Nigeria at intervals of one week for six months. These water samples were subjected to laboratory studies (Column, pH adjustment, Jar and residual chlorine tests). Laboratory analysis of flocs formation during coagulation, iron and microbes removal of chlorination process, pH adjustment and residual chlorine after treatment of the samples were conducted using standard methods in a bench scale and executed at prototype phase. Iso-concentration curves were developed from column tests to ascertain settle-ability of the flocs during treatment. The study revealed that optimum doses of coagulant and chlorination were 80 mg/l, and 10 mg/l, respectively for effective removal of iron and residual chlorine concentration of 3 mg/l. Flocs removal was 65 % of the influent flocs in the coagulated raw water at a depth of 1.2 m and at a retention time of 60 minutes. Analysis of iso-concentration curves revealed that overall flocs removal was 89 % at 60 minutes. This indicated that for a retention period of an hour 350 mg/l of flocs would be removed from the coagulated raw water. Removal of iron from the coagulated water was between 90 and 95 % of initial iron concentration of 1.42 mg/l and removal of microbes was 99.1 % at retention time of 40 minutes. It was concluded that Aponmu reservoir can be used as water source with little modification of the current facilities, but further studies are required to ascertain effects of other factors (quality of raw water, rainfall intensity, time of concentration, discharge rate) on quality of water production.