Browsing by Author "Obuotor, Efere M."

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    Comparative Evaluation of Antioxidant Properties of Methanol Extracts of Allium cepa bulb, Allium cepa bulb peels and Allium fistulosum.
    (Kragujevac J. Sci., 2018) Obuotor, Efere M.; Ola–Mudathir, Kikelomo F.; Wahab, Arogundade A.; Moshood, Abdullahi I.
    Medicinal plants have protective effects against many physiological diseases because of their phytochemical components which are better antioxidants. This study was aimed at comparing the in vitro antioxidant activity, phenolic and flavonoid content of the methanol extracts of Allium cepa bulb, Allium cepa bulb peel and Allium fistulosum. The antioxidant activity was determined by 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity, ferric reducing antioxidant power (FRAP), iron chelating activity and molybdate ion reduction assays. The total flavonoid and total phenolic content (TPC) were carried out using aluminium chloride and Folin-Ciocalteu assay respectively. The results showed that A. cepa bulb peel has the highest phenolic content and the antioxidant activity while the A. fistulosum showed the least. Furthermore, the total flavonoid content and metal iron chelating activity was highest in A. cepa bulb, while lowest values were obtained in A. fistulosum and A. cepa bulb peel respectively. The results suggest that the A. cepa bulb peel, A. cepa bulb and A. fistulosum extracts can be used as sources of natural antioxidants. However, A. cepa bulb peel may be the most potent.
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    Effect of ethanolic leaf extract of Croton zambesicus (Müll. Arg.) on lipid profile in streptozotocin-induced diabetic rats
    (Diabetol Croat, 2012-09) Ofusori, David A.; Komolafe, Omobola A.; Adewole, Olarinde S.; Obuotor, Efere M.; Fakunle, Julius B.; Ayoka, Abiodun O.
    Croton zambesicus (C. zambesicus) leaves have recently been identified as an antidiabetic agent in Africa. The aim of this study was to examine the effect of C. zambesicus leaf extract on lipid profile in experimentally induced diabetic rats. Seventy adult male Wistar rats were divided into seven groups (n=10): group A, control rats; group B, untreated diabetic rats; group C, diabetic rats in which C. zambesicus therapy started 2 weeks prior to induction of diabetes; group D, diabetic rats administered orally with C. zambesicus leaf extract for 2 weeks after the initial four weeks of diabetes induction; group E, diabetic rats administered orally with C. zambesicus leaf extract for 4 weeks after the initial four weeks of diabetes induction; group F, normal rats administered orally with C. zambesicus leaf extract for four weeks; and group G, diabetic rats administered with glimepiride (2 mg/kg/day) for four weeks after the initial four weeks of diabetes induction. At the end of the experimental period, the animals were weighed and sacrificed. Serum was obtained for lipid profile analysis using respective diagnostic kits. The results showed that the blood glucose level and body weights of extract and glimepiride treated groups were restored to the near normal level. The triglyceride, total cholesterol, low density lipoprotein and very low density lipoprotein cholesterol levels were increased significantly (P Key words: diabetes, lipid profile, Croton zambesicus, glimepiride, streptozotocin