Browsing by Author "Odeleye, O. M."

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    Changes in some biochemical parameters of kidney functions of Plasmodium berghei infected rats administered with some doses of artemether
    (Academic Journals, 2012) Akomolafe, R. O.; Adeoshun, I. O.; Fakunle, Julius B.; Iwalewa, E. O.; Ayoka, A. O.; Ajayi, O. E.; Odeleye, O. M.; Akanji, B. O.
    This study aimed at determining changes in urine concentrations of sodium (Na+) and potassium (K+) of Plasmodium berghei infected rats during a week of intramuscular administration of artemether (12.5 to 50.0 mg/kg/day) and one week thereafter. Their concentrations and that of creatinine and urea in the plasma were also determined at the end of the study. The observed changes were related to the effects of artemether on the kidneys of the rats. The urine levels of the two electrolytes decreased significantly during treatment (P< 0.05). One week post-treatment with 12.5 mg/kg of artemether, the urine concentrations of the electrolytes increased to values that were not significantly different from that of day 0. At 25 and 50 mg/kg, their urine concentrations still remained significantly lower than day 0 values (P< 0.05). Plasma concentrations of the electrolytes one week post-treatment increased, but they were only significant at 25 mg/kg for K+. A significant increase in the plasma level of creatinine was observed at all the doses of the drug at one week post-treatment. A dose-dependent degeneration of the renal tissue of all the experimental rats was also observed. We concluded that high doses of artemether caused progressive degeneration of the renal tissue of P. berghei infected rats.
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    Effects of artemether on biochemical markers of liver function in Plasmodium berghei-infected and non-infected rats
    (Academic Journals (Kenya), 2013) Akomolafe, Rufus Ojo; Adeoshun, I. O.; Fakunle, Julius B.; Iwalewa, E. O.; Ayoka, A. O.; Ajayi, O. E.; Odeleye, O. M.; Akanji, B. O.
    This study aimed at determining changes in plasma activities of some enzymes and concentrations of plasma organic constituents which are often used in the assessment of liver functions in uninfected rats (UNR) and Plasmodium berghei infected rats (INR), following a week of intramuscular administration of artemether (12.5 to 50.0 mg/kg/day). The observed changes were related to the effects of artemether on the liver of the rats. At all the doses tested, the plasma concentrations of total and conjugated bilirubin increased significantly in both INR and UNR. A significant decrease in the plasma concentrations of glucose was also observed in UNR. The levels of cholesterol were significantly higher in INR than UNR. Plasma glutamate oxaloacetate transaminase (GOT) activity was significantly increased in both categories of rats, but more significantly in INR. The activity of plasma glutamate pyruvate transaminase (GPT) increased significantly at 12.5 and 25.0 mg/kg only in UNR, while a significant increase was observed at 50.0 mg/kg in the INR. Photomicrograph of the liver revealed progressive tissue damage which was more pronounced in INR than UNR. We concluded that high doses of artemether are toxic to the liver of both infected and uninfected rats.
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    Effects of artemether on the plasma and urine concentrations of some electrolytes in rats
    (Academic Journals (Kenya), 2011) Akomolafe, R. O.; Adeoshun, I. O.; Fakunle, Julius. B.; Iwalewa, E. O.; Ayoka, A. O.; Ajayi, O. E.; Odeleye, O. M.; Akanji, B. O.
    This study was carried out to determine the changes in the urine levels of sodium (Na+), potassium (K+), and calcium (Ca 2+) of rats during a week of intramuscular administration of artemether (12.5 to 50.0 mg/kg/day), another one week thereafter and their concentrations in the plasma at the end of the study. At 12.5 and 25.0 mg/kg of artemether, urine Na+ concentration was significantly increased throughout the study (p< 0.05), except on Day 7 (at 12.5 mg/kg) and Day 11 (at 25.0 mg/kg), when it was not significantly different from the control. At 12.5 mg/kg of the drug, urine K+ concentration was significantly increased throughout the study (p< 0.05). Artemether caused no significant changes in urine Ca 2+ concentration in the control rats as well as those that received 12.5 and 25.0 mg/kg of artemether. Progressive and significant reductions in the urine concentrations of all the electrolytes at 50.0 mg/kg of artemether were observed. Their concentrations in the plasma were also significantly reduced at this dose of the drug. A dose-dependent degeneration of the renal tissue of all the experimental rats was also observed. We concluded that high doses of artemether caused progressive degeneration of the renal tissue of rats, inability of the damaged kidneys to concentrate urine, which manifested as excessive water loss and electrolyte depletion.