Browsing by Author "Onile, O.S"
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Item Selection of T cell epitopes from S. mansoni Sm23 protein as a vaccine construct, using immunoinformatics approach(Journal of Computational Biology and Bioinformatics Research, 2017-01) Onile, O.S; Fadare, Shadrach Olaleka; Ofelia, Omitogun G.Schistosomiasis, a neglected and most prevalenttropical diseases after malaria, have been a threat to people living in endemic areas. With regards to possible resistance to the popular drug (praziquantel) use for treatment of schistosomiasis, the need for a permanent vaccinating approach has been justified. This study uses an in silico approach to identify potential target vaccine candidate or T cell epitopes (T cell response activating epitope) for the treatment of schistosomiasis. This research therefore identified some candidate T cell epitopes from Sm23 protein of Schistosma mansoni using immunoinformatics tools. Nonameric epitopes like 85YMYAFFLVV93, 83MLYMYAFFL91, 8MRCLKSCVF16, 41SQYGDNLHK49 and 104VAVVYKDRI112 was found to exhibit strong binding affinity with some human leukocyte antigen (HLA). The predicted epitope was found to have no similarity with human proteome, a good attribute that is conferred on any good vaccine candidate. The predicted epitopes provide promising drug candidates and could be tested by wet laboratory as targeted vaccine against S. mansoni infection.Item Socio-cultural and environmental determinants of a proposed schistosomiasis health education intervention in Eggua, Nigeria(JOURNAL OF BEHAVIORAL HEALTH, 2019-08-29) Anumudu, Chiaka I.; Onile, O.S; Awobode, Henrietta; Gboyega-Tokunbo, Anuoluwapo; Oladele, Victoria; Adebayo, Adewale; Chouvwen, Catherine O.Background: Central to the utility of health education in the control of schistosomiasis is an understanding of the way a community perceives, understands, and can explain how schistosomiasis occurs among them. Methods: In order to study the environmental, social, and cultural determinants of continued schistosomiasis prevalence in Eggua, we administered semi-structured questionnaires to 372 adults between November 2012 and December 2015 which asked about the perceptions, understanding of the community and the patterns of schistosomiasis. Results: The respondents’ ages ranged from 35 to above 60 years. 44.7% had no schooling and 39.6% had at least primary education. 48.4% were farmers, 29.8% traders, and 1.6% fisher-folk. Majority (79%, 95% CI 76.5–83.0) were of a Christian denomination where members spend long periods in the river praying. Water contact was frequent with 89.5% visiting the rivers daily. Despite the research surveys taking place in Yewa since 2009, 81.5% of respondents did not know the cause of blood in urine, and self-reported hematuria was low, 4.6%. Latrine use was negligible, up to 95% of respondents did not have a latrine. Those who had heard about schistosomiasis were not well educated on prevention methods; 89.5% did not know they could be re-infected after the treatment. Conclusion: Formal Health Education initiatives which consider these findings should be designed for the control of schistosomiasis in Eggua.