Browsing by Author "Oyagbemi, Ademola Adetokunbo"

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    Ficus asperifolia Miq-enriched biscuit diet protects against L-NAME induced hyperlipidemia and hypertension in rats
    (Food Frontiers, 2021-06) Ajeigbe, Olufunke Florence; Oboh, Ganiyu; Ademosun, Ayokunle Olubode; Oyagbemi, Ademola Adetokunbo
    Dietary sources of functional foods and nutraceutical have shown strong potentials in the management of hypertension and its complications. Sandpaper leaves, Ficus asperifolia Miq (FA), particularly found in Africa has a rich folkloric history in the management of diabetes and hypertension. This study produced biscuits supplemented with blends of FA at 2.5% and 5% fed to Nw (G)-nitro-L-arginine-methyl-ester (L-NAME, 40 mg/kg/day) induced-hypertensive rats for 14 days followed by the assessment of blood pressure, lipid profile, and atherogenic index in hypertensive rats. The phenolic constituents of FA blends were analyzed using high-performance liquid chromatography diode-anode (HPLC-DAD). Thereafter, the mean arterial blood pressure (MABP) and systolic blood pressure (SBP) was measured using the tail-cuff method afterwhich the heart and lungs of ratswere collected, weighed, and the antioxidant status and lipid cholesterol profile were assessed. We realized that recorded phenolic constituents in extracts of FA was at a high level and FA enriched biscuit-diet caused a significant decrease in SBP and MABP in L-NAME-induced hypertensive rats, body weight, atherogenic index and cholesterol profile in treated rats. However, FA enriched biscuit resulted in increased activities of catalase (CAT), superoxide dismutase (SOD), and glutathione-S-transferase (GST) antioxidant enzymes in the heart and lungs of hypertensive rats. This study revealed that FA enriched biscuit-diet does not only have antihypertensive and antioxidant potential in L-NAME-induced hypertensive rats but also plays a protective role in themanagement of hyperlipidemia.
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    Fig leaves varieties reduce blood pressure in hypertensive rats through modulation of antioxidant status and activities of arginase and angiotensin-1 converting enzyme
    (Springer Link : Comparative Clinical Pathology, 2021-05) Ajeigbe, Olufunke F.; Oboh, Ganiyu; Ademosun, Ayokunle Olubode; Oyagbemi, Ademola Adetokunbo
    The medicinal application of sandpaper leaves in the management of hypertension has been reported with very little knowledge on the variety with better anti-hypertensive properties. Hence, this study seeks to compare phenolic content and the effect of some varieties of sand paper leaves (Ficus spp.), namely, Ficus exasperata (FE), Ficus asperifolia (FA), Ficus mucuso (FM) and Ficus capensis (FC) on the systolic and diastolic bood pressures (SBP and DBP), angiotensin-1-converting enzyme (ACE), and arginase activities and antioxidant status in L-NAME induced hypertensive rats. The animals were divided into eleven groups (n = 6): normotensive control rats, hypertensive rats, hypertensive rats treated with atenolol (10 mg/kg/day), hypertensive rats treated with 2.5% and 5% FE, FA, FM, and FC extract inclusive diet respectively. There was a significant rise (p < 0.05) in the systolic and diastolic blood pressures, ACE and arginase activities, and antioxidant status in the hypertensive rats. However, there were reductions in the SBP, DBP, ACE, and arginase activities and increase in the antioxidant status of the rats fed with the Ficus leaves. FM had the highest phenolic (91.09 mg/100 g) and flavonoid content (43.35 mg/100 g). FA showed the best anti-oxidant property, while FC showed the strongest inhibition of ACE and arginase activities.