Browsing by Author "Oyeyemi, A. O."

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    Biochemical changes associated with sickle cell anaemia
    (Biosciences Biotechnology Research Asia, 2015-05-02) Asaolu, M. F.; Oyeyemi, A. O.; Fakunle, Julius B.; Ajose, A. O.
    Some blood chemical parameters including some enzyme activities were determined in forty two sickle cell patients in Ekiti state, Nigeria. All the parameters of interest analyzed for were found present in all the samples. The mean values for uric acid (0.35±0.16 mol/l), creatinine (100.55±8.13 μmol/l), urea (10.50±6.28 mmol/l), Total bilirubin (14.42±2.03 μmol/l), conjugated bilirubin (10.53±2.67 μmol/l), alkaline phosphatase (82.67±10.87 μ/l) aspartate transaminase (SGOT)(20.68±9.85 μ/l) and alanine transaminase (SGPT)(28.68±9.85 μ/L) were significantly higher (P< 0.05) in sickle cell patients than the control. Serum sodium (Na+)(110.00±4.0 lmmol/L), potassium (K+)(2.56±0.63 mmol/L) total protein (60.05±10.35 g/L), albumin (30.16±3.28 g/L), Calcium (2.00±0.1 mmol/L) and inorganic phosphate (1.12±0.19 mmol/L) were also found to be significantly lowered in sickle cell patient when compared with the control. Analysis of the results showed an increase in plasma chloride (99.33±2.54 mmol/L) and decrease in bicarbonate (22.99±2.06 mmol/L). The differences were however not statistically significant (P> 0.05). The significant raised level of SGPT, SGOT, ALP, total bilirubin, conjugated bilirubin, and significant lower levels of total protein, albumin, calcium, inorganic phosphate indicates that there may be abnormal liver and renal function as well as muscular and bone dysfunction in these patients.
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    A comparative study of serum ferritin and other acute phase reactants (APR) in minor and major surgery
    (Academic Journals, 2009-12-31) Asaolu, M. F.; Oyeyemi, A. O.; Fakunle, Julius B.
    This study was carried out on serum ferritin, acute phase reactants (APR), iron (Fe) and total iron binding capacity (TIBC) in healthy women in Ado Ekiti, Nigeria and in female patients undergoing suture (minor operation) and ceaserean operations at the Obafemi Awolowo University Teaching Hospital Complex, Ile-Ife, Nigeria between February and March, 2009. The results revealed post-operative serum ferritin and APR concentrations to be significantly higher (p> 0.01) while iron and TIBC were significantly lower in patients undergoing caesarean operation compared to both patients with minor operation and healthy women. The pre-operative results of serum ferritin were however significantly lower in patient undergoing major operation than in patients with minor operation. The present study was carried out to examine the changes in serum ferritin and other acute phase reactants in response to the magnitude of tissue damage. It can be concluded that the concentrations of serum ferritin and acute phase reactant increases as the magnitude of tissue damages increases. There is an acute phase response of serum ferritin levels following major surgery.