Antihyperlipidaemic and Antioxidant Potential of Fermented Citrullus vulgaris Seeds (Thunb.) on Tyloxapol-induced Hyperlipidaemic Rats: A Comparison With Fluvastatin
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Date
2015-08-01
Journal Title
Journal ISSN
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Publisher
Canadian Center of Science and Education
Abstract
Globally fermented foods form an integral part of the staple diet of people. Fermented Citrullus vulgaris (FCV)
(ogiri) seeds is a nutritious natural fermented condiment that features frequently in West African diets as a spice.This study investigated the antihyperlipidaemic potential of this condiment in tyloxapol-induced hyperlipidaemic rats with reference to that of fluvastatin, a standard antilipidaemic drug. The antioxidant potential of the condiment was also examined using different relevant in vitro assays. Albino rats were divided into six groups (n=5), based on the diet and treatment received. The groups were standard feed (control); FCV supplemented feed; standard feed with tyloxapol administered at the end of the experimental period (tyloxapol control); FCV supplemented feed and tyloxapol at the end of the experimental period; standard feed with fluvastatin sodium (40 mg/kg and 80 mg/kg body weight separately) followed by tyloxapol. The results revealed that administration of tyloxapol induced significant (p < 0.05) increase in total-cholesterol (TC), low density lipoprotein cholesterol (LDL-C) and triglyceride (TG). These lipid increases were significantly mitigated in groups initially pre-fed with supplemented FCV feed. Plasma TC decreased by 69.38% (p < 0.05); TG by 80.58% (p < 0.05); LDL-C by 7.80% (p < 0.05) and high density lipoprotein cholesterol (HDL-C) levels increased by 78.61% (p < 0.05). FCV showed appreciable antioxidant activities in vitro in a dose dependent manner. Histomorphological examination of the liver suggested that the FCV possessed hepatoprotective potential. These results suggest that FCV consumption may be a possible dietary measure for the control of dyslipidaemia.
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Keywords
Fermented Citrullus vulgaris, Ogiri, Fluvastatin, HDL-C, Hyperlipidaemia, LDL-C, Total-cholesterol, Triglyceride, Tyloxapol
Citation
Ayo-Lawal, A. R., Osoniyi, O., & Famurewa, A. J. (2015). Antihyperlipidaemic and Antioxidant Potential of Fermented Citrullus vulgaris Seeds (Thunb.) on Tyloxapol-induced Hyperlipidaemic Rats: A Comparison With Fluvastatin. Journal of Food Research, 4(4), 110.