Screening of Ameloblastoma Cases in Ibadan for HPV and EBV Genes.
| dc.contributor.author | Onile, Olugbenga S. | |
| dc.contributor.author | Onyegbula, K. | |
| dc.contributor.author | Okoje, V. | |
| dc.contributor.author | Anumudu, C. I. | |
| dc.date.accessioned | 2019-07-05T08:25:20Z | |
| dc.date.available | 2019-07-05T08:25:20Z | |
| dc.date.issued | 2013-10-02 | |
| dc.description.abstract | Context: This study investigated the presence or absence of β-catenin and Patched1 (PTCH1) genes involved in the developmental pathway in ameloblastoma, in order to clarify the genetic etiology of this tumor. Aim: The aim of this study was to investigate whether PTCH1 and β-catenin genes are involved in the development of ameloblastoma. Subjects and Methods: Archived formalin-fixed paraffinembedded specimens of 89 ameloblastoma cases from the year 2000 to 2010 were genotyped by polymerase chain reaction (PCR). Results: A total of 21 (23.6%) of the 89 ameloblastoma cases were positive for β-catenin gene, where 14/21 (66.7%) cases were mandibular ameloblastoma. Plexiform 5/21 (23.8%) and cystic 5/21 (23.8%) ameloblastoma were the most regular histological type positive for β-catenin. However, β-catenin positive was more in the feminine gender (11/19, 57.9%) than the masculine (8/19, 42.1%). Only one case was positive for PTCH1 gene and this was histologically a mandibular site and plexiform-type ameloblastoma. Conclusions: This study suggested that β-catenin and PTCH1 genes may play an important role in the pathogenesis of ameloblastoma. | en_US |
| dc.identifier.uri | 10.13189/cor.2013.010202 | |
| dc.identifier.uri | http://repository.elizadeuniversity.edu.ng/handle/20.500.12398/273 | |
| dc.language.iso | en | en_US |
| dc.publisher | Horizon Research Publishing | en_US |
| dc.subject | Ameloblastoma | en_US |
| dc.subject | β-catenin | en_US |
| dc.subject | Odontogenic | en_US |
| dc.subject | Patched | en_US |
| dc.title | Screening of Ameloblastoma Cases in Ibadan for HPV and EBV Genes. | en_US |
| dc.type | Article | en_US |