Bioprospecting marine actinomycetes for antileishmanial drugs: current perspectives and future prospects
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Date
2021-07-30
Journal Title
Journal ISSN
Volume Title
Publisher
Heliyon by cepress
Abstract
Revived analysis interests in natural products in the hope of discovering new and novel antileishmanial drug leads
have been driven partially by the increasing incidence of drug resistance. However, the search for novel chemotherapeutics
to combat drug resistance had previously concentrated on the terrestrial environment. As a result,
the marine environment was often overlooked. For example, actinomycetes are an immensely important group of
bacteria for antibiotic production, producing two-thirds of the known antibiotics. However, these bacteria have
been isolated primarily from terrestrial sources. Consequently, there have been revived efforts to discover new
compounds from uncharted or uncommon environments like the marine ecosystem. Isolation, purification and
structure elucidation of target compounds from complex metabolic extract are major challenges in natural
products chemistry. As a result, marine-derived natural products from actinomycetes that have antileishmanial
bioactivity potentials have been understudied. This review highlights metagenomic and bioassay approaches
which could help streamline the drug discovery process thereby greatly reducing time and cost of dereplication to
identify suitable antileishmanial drug candidates.
Description
staff publication
Keywords
Antileishmanial, Actinomycetes, Marine-resources, Metagenomic, Drug discovery
Citation
Davies-Bolorunduro, O. F., Osuolale, O., Saibu, S., Adeleye, I. A., & Aminah, N. S. (2021). Bioprospecting marine actinomycetes for antileishmanial drugs: current perspectives and future prospects. Heliyon, 7(8), e07710. doi:10.1016/j.heliyon.2021.e0771