Selection of T cell epitopes from S. mansoni Sm23 protein as a vaccine construct, using Immunoinformatics approach
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Date
2018-05
Journal Title
Journal ISSN
Volume Title
Publisher
Academic Journals
Abstract
Schistosomiasis, a neglected and most prevalenttropical diseases after malaria, have been a threat to
people living in endemic areas. With regards to possible resistance to the popular drug (praziquantel)
use for treatment of schistosomiasis, the need for a permanent vaccinating approach has been
justified. This study uses an in silico approach to identify potential target vaccine candidate or T cell
epitopes (T cell response activating epitope) for the treatment of schistosomiasis. This research
therefore identified some candidate T cell epitopes from Sm23 protein of Schistosma mansoni using
immunoinformatics tools. Nonameric epitopes like 85YMYAFFLVV93
,
83MLYMYAFFL91
,
8MRCLKSCVF16
,
41SQYGDNLHK49 and 104VAVVYKDRI112 was found to exhibit strong binding affinity with some human
leukocyte antigen (HLA). The predicted epitope was found to have no similarity with human proteome, a
good attribute that is conferred on any good vaccine candidate. The predicted epitopes provide
promising drug candidates and could be tested by wet laboratory as targeted vaccine against S.
mansoni infection.
Description
Keywords
Schistosomiasis, T-cell epitopes, human leukocyte antigen (HLA), vaccines
Citation
Onile, O. S., Fadare, S. O., & Omitogun, G. O. (2018). Selection of T cell epitopes from S. mansoni Sm23 protein as a vaccine construct, using Immunoinformatics approach. Journal of Computational Biology and Bioinformatics Research, 8(1), 1-11