Selection of T cell epitopes from S. mansoni Sm23 protein as a vaccine construct, using Immunoinformatics approach

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dc.contributor.authorOnile, Olugbenga S.
dc.contributor.authorFadare, Olalekan S.
dc.contributor.authorOmitogun, Ofelia G.
dc.date.accessioned2019-07-22T15:51:32Z
dc.date.available2019-07-22T15:51:32Z
dc.date.issued2018-05
dc.description.abstractSchistosomiasis, a neglected and most prevalenttropical diseases after malaria, have been a threat to people living in endemic areas. With regards to possible resistance to the popular drug (praziquantel) use for treatment of schistosomiasis, the need for a permanent vaccinating approach has been justified. This study uses an in silico approach to identify potential target vaccine candidate or T cell epitopes (T cell response activating epitope) for the treatment of schistosomiasis. This research therefore identified some candidate T cell epitopes from Sm23 protein of Schistosma mansoni using immunoinformatics tools. Nonameric epitopes like 85YMYAFFLVV93 , 83MLYMYAFFL91 , 8MRCLKSCVF16 , 41SQYGDNLHK49 and 104VAVVYKDRI112 was found to exhibit strong binding affinity with some human leukocyte antigen (HLA). The predicted epitope was found to have no similarity with human proteome, a good attribute that is conferred on any good vaccine candidate. The predicted epitopes provide promising drug candidates and could be tested by wet laboratory as targeted vaccine against S. mansoni infection.en_US
dc.identifier.citationOnile, O. S., Fadare, S. O., & Omitogun, G. O. (2018). Selection of T cell epitopes from S. mansoni Sm23 protein as a vaccine construct, using Immunoinformatics approach. Journal of Computational Biology and Bioinformatics Research, 8(1), 1-11en_US
dc.identifier.issn2141-2227
dc.identifier.uri10.5897/JCBBR2016.0109
dc.identifier.urihttp://repository.elizadeuniversity.edu.ng/handle/20.500.12398/376
dc.language.isoenen_US
dc.publisherAcademic Journalsen_US
dc.subjectSchistosomiasisen_US
dc.subjectT-cell epitopesen_US
dc.subjecthuman leukocyte antigen (HLA)en_US
dc.subjectvaccinesen_US
dc.titleSelection of T cell epitopes from S. mansoni Sm23 protein as a vaccine construct, using Immunoinformatics approachen_US
dc.typeArticleen_US
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