EVALUATION OF GARLIC EXTRACTS ON CANCER GROWTH IN RATS FED DIETS WITH VARYING LEVELS OF PROTEIN.
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Date
1984
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Publisher
Howard University
Abstract
Several aqueous plant extracts of common vegetables were screened for
in vitro inhibition of tumor guanylate cyclase activity (the only enzyme
known which produces cyclic GMP, a key regulator of cancer cell
growth). One hundred and twenty young male rats (100-133g) were
assigned to two major groups. One group of sixty animals was injected
with transplantable Morris hepatoma (#3924A) one week after they had
been placed onto their dietary regimen. Each major group was divided
into six minor groups of ten rats each and was fed with three dietary
protein levels of either 5%, 15% and 25% (without and with 5%
lypholized garlic extract supplement). Non-tumor bearing animals fed
5% or 15% protein ate significantly (p < 0.05) more food than the tumorbearing animals (10.8 vs 9.3g). At the end of four weeks, dietary protein
showed a significantly positive correlation with liver weight, kidney
weight, tumor weight, tumor area and tumor tissue protein (p < 0.01).
Serum and liver protein were significantly decreased in the tumor
bearing animals. Low dietary protein significantly decreased tumor
growth (p < 0.05) from 60-70%. All diets containing 5% garlic yielded
decreased tumor growth from 10-25% (p < 0.05). Results of this study
indicate that a decrease in dietary protein and/or a 5% garlic extract
dietary supplement caused decreased growth of Morris hepatoma
3924A. It appears that garlic extract supplemented in the diet of
experimental animals may help in cancer prevention.
Description
Keywords
Garlic Extracts, Cancer Growth In Rats Fed Diets, Levels Of Protein
Citation
Fakunle, J. B. (1984). EVALUATION OF GARLIC EXTRACTS ON CANCER GROWTH IN RATS FED DIETS WITH VARYING LEVELS OF PROTEIN.