Browsing by Author "Oladunmoye, M. K."
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Item Comparative antibacterial studies of mistletoes growing on two diffrent host plants in Akure North, Nigeria(Inter. J. Medic. Med. Sci, 2013-11) Yusuf, L.; Oladunmoye, M. K.; Ogundare, A. O.; Akinyosoye, F. A.; Hassan, G. F.; Momoh, Abdul O.The antibacterial activity of 60 % methanolic leaves extracts of mistletoes (Viscum album) growing on cocoa and cola trees were tested on Bacillus cereus, Pseudomonas aeruginosa,Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Salmonella typhi in vitro. Both the gram-positive and gramnegative organisms showed variable sensitivity to the extracts treatments. The results obtained indicated that extracts from both host plants had some antibacteria activities against the microorganisms when compared with standard antimicrobial agents (ciprofloxacin and sterptomycin) used as positive controls at P < 0.05 significant level. In general,extracts from cocoa (Theobroma cacao) plant showed more antimicrobial tendency than those from cola (Kola nitida) plant.Item Evaluation of the antimicrobial and phytochemical properties of oil from castor seeds (Ricinus communis Linn)(Bulletin of Environment, Pharmacology and Life Sciences, 2012-09-10) Momoh, Abdul O.; Oladunmoye, M. K.; Adebolu, T. T.The antimicrobial activity of the essential oil of castor (Ricinus communis) seeds extracted using soxhlet extractor in 98% nhexane was assessed using in-vitro assay. Twenty microorganisms made up of fourteen bacteria and six fungi were used in the bioassay. Comparatively, bacteria were found to be more susceptible than fungi. The minimum inhibitory concentration (MIC) of the extract was found to range between 6.25 mg/ml and 12.50 mg/ml for bacteria while that of fungi ranged from 12.50 mg/ml to 25.00 mg/ml. Comparison of the antimicrobial efficacy of the extract and commercial antibiotics showed that the latter were more potent against the test organisms with the exceptions of erythromycin, ampiclox and rifampin group for Gram positive organisms and, septrin and ceporex group for Gram negative organisms respectively. The quantitative phytochemical screening showed that tannin, phenol, alkaloid, phytate, oxalate, saponin, cyanogenic glycoside and flavonoid were present in a decreasing order. The spectrophotometric data of the extract using ultraviolet radiation, infrared and HNMR as well as carbon 13 NMR showed the presence of various compounds such as cineole, 2-octanol, terpenene-4-ol, limonene, sabinene, pinene, terpinene, and methyl groups in the oil.Item Haematological and histopathological effects of oil from castor seeds (Ricinus communis Linn.) on albino-rats(Academic Journals, 2012-07) Momoh, Abdul O.; Oladunmoye, M. K.; Adebolu, T. T.The effects of soxhlet extraction of oil from castor seeds (Ricinus communis Linn) using n-hexane as solvent on hematological and histopathological properties of albino rats was investigated using standard method. The haematological analysis of the animals’ blood showed that the extract caused a reduction in the packed cell volume (PCV) from 49.3 to 46.7%. Histopathological analysis of the organs of the animals showed that the extract caused dilation of the sinusoid with less prominent nucleus of the liver, homogeneity of the muscle fibres of the heart with inflammatory cell infiltration, infiltration of kidney cells with increased hyaline casts, while the small intestine showed acute erosion of superficial and middle parts of the intestinal villi. Since the oil has deleterious effects on the organs of the animals used and also reduced the PCV, it is conceivable that when the oil is consumed by humans, it will have the same effect. Therefore, it is advocated that the oil should not be consumed until further work is done on it.