Taurine Ameliorates Renal Oxidative Damage and Thyroid Dysfunction in Rats Chronically Exposed to Fluoride

Simple item page
dc.contributor.authorAdedara, Isaac A.
dc.contributor.authorOjuade, Temini Jesu D.
dc.contributor.authorOlabiyi, Bolanle F.
dc.contributor.authorIdris, Umar F.
dc.contributor.authorOnibiyo, Esther M.
dc.contributor.authorAjeigbe, Olufunke F.
dc.contributor.authorFarombi, Ebenezer O.
dc.date.accessioned2021-06-07T12:41:43Z
dc.date.available2021-06-07T12:41:43Z
dc.date.issued2016-06-26
dc.descriptionStaff Publicationen_US
dc.description.abstractExcessive exposure to fluoride poses several detrimental effects to human health particularly the kidney which is a major organ involved in its elimination from the body. The influence of taurine on fluoride-induced renal toxicity was investigated in a co-exposure paradigm for 45 days using five groups of eight rats each. Group I rats received normal drinking water alone, group II rats were exposed to sodium fluoride (NaF) in drinking water at 15 mg/L alone, group III received taurine alone at a dose of 200 mg/kg group IV rats were co-administered with NaF and taurine (100 mg/kg), while group V rats were co-administered with NaF and taurine (200 mg/kg). Administration of taurine significantly reversed the fluoride-mediated decrease in absolute weight and organo-somatic index of the kidney in the exposed rats. Taurine significantly prevented fluoride-induced elevation in plasma urea and creatinine levels in the exposed rats. Moreover, taurine restored fluoride-mediated decrease in the circulatory concentrations of triiodothyronine, thyroxine, and the ratio of triiodothyronine to thyroxine. Taurine ameliorated fluoride-mediated decrease in renal antioxidant status by significantly enhancing the antioxidant enzyme activities as well as glutathione level in the exposed rats. Additionally, taurine inhibited fluoride-induced renal oxidative damage by markedly decreasing the hydrogen peroxide and malondialdehyde levels as well as improved the kidney architecture in the treated rats. Collectively, taurine protected against fluoride-induced renal toxicity via enhancement of thyroid gland function, renal antioxidant status, and histology in rats.en_US
dc.identifier.citationAdedara, I.A., Ojuade, T.J.D., Olabiyi, B.F. et al. Taurine Ameliorates Renal Oxidative Damage and Thyroid Dysfunction in Rats Chronically Exposed to Fluoride. Biol Trace Elem Res 175, 388–395 (2017). https://doi.org/10.1007/s12011-016-0784-2en_US
dc.identifier.urihttps://doi.org/10.1007/s12011-016-0784-2
dc.identifier.urihttp://repository.elizadeuniversity.edu.ng/handle/20.500.12398/1104
dc.language.isoenen_US
dc.publisherSpringer Link : Biological Trace Element Research volumeen_US
dc.subjectFluorideen_US
dc.subjectTaurineen_US
dc.subjectRenal toxicityen_US
dc.subjectThyroid hormonesen_US
dc.subjectRatsen_US
dc.titleTaurine Ameliorates Renal Oxidative Damage and Thyroid Dysfunction in Rats Chronically Exposed to Fluorideen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Pages from adedara2016.pdf
Size:
168.48 KB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.61 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Research Articles in Physical and Chemical Sciences