Iron status in HIV-1 infection: implications in disease pathology

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dc.contributor.authorBanjoko, Olatunbosun S.
dc.contributor.authorOseni, Falilat A.
dc.contributor.authorTogun, Rachel A.
dc.contributor.authorOnayemi, Olaniyi
dc.contributor.authorEmma-Okon, Beatrice O.
dc.contributor.authorFakunle, Julius B.
dc.date.accessioned2019-07-31T12:22:56Z
dc.date.available2019-07-31T12:22:56Z
dc.date.issued2012-12
dc.description.abstractThere had been conflicting reports with levels of markers of iron metabolism in HIV infection. This study was therefore aimed at investigating iron status and its possible mediation of severity of HIV- 1 infection and pathogenesis. Eighty (80) anti-retroviral naive HIV-1 positive and 50 sero-negative controls were recruited for the study. Concentrations of serum total iron, transferrin, total iron binding capacity (TIBC), CD4 + T -lymphocytes, vitamin C, zinc, selenium and transferrin saturation were estimated. The mean CD4 + T-lymphocyte cell counts, serum iron, TIBC, transferrin saturation for the tests and controls were 319 ± 22, 952 ± 57 cells/μl (P < 0.001), 35 ± 0.8, 11.8 ± 0.9 μmol/l (P < 0.001), 58.5 ± 2.2, 45.2 ± 2.4 μmol/l (P < 0.005) and 68.8 ± 3.3, 27.7 ± 2.2%, (P <0.001), respectively, while mean concentrations of vitamin C, zinc and selenium were 0.03 ± 0.01, 0.3 ± 0.04 (P < 0.001), 0.6 ± 0.05, 11.9 ± 0.26 μmol/l (P < 0.001) and 0.1 ± 0.01, 1.2 ± 0.12 μmol/l (P < 0.001) respectively. Furthermore, CD4 + T-lymphocyte cell count had a positive correlation with levels of vitamin C (r = 0.497, P < 0.001), zinc (r = 0.737, P < 0.001), selenium (r = 0.639, P < 0.001) and a negative correlation with serum iron levels (r = −0.572, P < 0.001). It could be inferred that derangement in iron metabolism, in addition to oxidative stress, might have contributed to the depletion of CD4 + T cell population in our subjects and this may result in poor prognosis of the disease.en_US
dc.identifier.citationBanjoko, S. O., Oseni, F. A., Togun, R. A., Onayemi, O., Emma-Okon, B. O., & Fakunle, J. B. (2012). Iron status in HIV-1 infection: implications in disease pathology. BMC Clinical Pathology, 12(1), 26.en_US
dc.identifier.issn1472-6890
dc.identifier.urihttp://repository.elizadeuniversity.edu.ng/handle/20.500.12398/433
dc.language.isoenen_US
dc.publisherBioMed Centralen_US
dc.subjectIron metabolismen_US
dc.subjectHIV-1 infectionen_US
dc.subjectPathogenesisen_US
dc.subjectPrognosisen_US
dc.subjectAntioxidanten_US
dc.subjectFree radicalsen_US
dc.titleIron status in HIV-1 infection: implications in disease pathologyen_US
dc.typeArticleen_US
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