Modulatory Effects of Ferulic Acid on Cadmium-Induced Brain Damage

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dc.contributor.authorAdefegha, Stephen A.
dc.contributor.authorOmojokun, Olasunkanmi S.
dc.contributor.authorOboh, Ganiyu
dc.contributor.authorFasakin, Olasunkanmi
dc.contributor.authorOgunsuyi, Opeyemi
dc.date.accessioned2021-02-09T10:23:37Z
dc.date.available2021-02-09T10:23:37Z
dc.date.issued2015-11-16
dc.descriptionStaff Publicationen_US
dc.description.abstractStudies have shown the pharmacological relevance of phenolics like ferulic acid (FA) in promoting health. This study sought to investigate the modulatory effects of FA on cadmium-induced brain damage in rats. Brain damage was induced in Wistar strain rats by oral administration of cadmium (5 mg/kg body weight) for 21 days. Assays for malondialdehyde (MDA) content, acetylcholinesterase (AChE), butyrylcholinesterase (BChE), monoamine oxidase (MAO), and Naþ/Kþ-ATPase activities were carried out. The study revealed significant (P < .05) increases in the MDA content and all enzymes’ (AChE, BChE, MAO, and Naþ/Kþ- ATPase) activity investigated following cadmium administration. However, rats administered FA (10 and 20 mg/kg body weight) alongside cadmium significantly (P < .05) protected the brain by reversing the level of lipid peroxidation as measured by the MDA content as well as the enzymes’ activity. This study, therefore, substantiates the neuroprotective potentials of FA especially in the management of cadmium-induced toxicity.en_US
dc.identifier.citationAdefegha, S. A., Omojokun, O. S., Oboh, G., Fasakin, O., & Ogunsuyi, O. (2016). Modulatory Effects of Ferulic Acid on Cadmium-Induced Brain Damage. Journal of Evidence-Based Complementary & Alternative Medicine, 21(4), NP56–NP61. doi:10.1177/2156587215621726en_US
dc.identifier.uriDOI: 10.1177/2156587215621726
dc.identifier.urihttp://repository.elizadeuniversity.edu.ng/handle/20.500.12398/822
dc.language.isoenen_US
dc.publisherSAGEen_US
dc.subjectCadmium,en_US
dc.subjectFerulic acid,en_US
dc.subjectCholinesterasesen_US
dc.subjectMonoamine oxidase,en_US
dc.subjectNaþ/Kþ-ATPase,en_US
dc.subjectMalondialdehydeen_US
dc.titleModulatory Effects of Ferulic Acid on Cadmium-Induced Brain Damageen_US
dc.typeArticleen_US
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