Modulatory effect of protocatechuic acid on cadmium induced nephrotoxicity and hepatoxicity in rats in vivo

Simple item page
dc.contributor.authorAdefegha, Stephen A.
dc.contributor.authorOmojokun, Olasunkanmi S.
dc.contributor.authorOboh, Ganiyu
dc.date.accessioned2020-01-30T16:10:34Z
dc.date.available2020-01-30T16:10:34Z
dc.date.issued2015-12-01
dc.description.abstractIntroduction: This study sought to investigate the effect of protocatechuic acid (PCA); a phenolic compound readily available in most plant foods on cadmium-induced nephrotoxicity and hepatoxicity in rats. Case description: Thirty six adult male rats weighing about 150–160 g were acclimatized for 2 weeks and subsequently divided into six groups: Group 1 rats received normal saline (control group), group 2 rats were administered 5 mg Cd/kg body weight in form of solution orally (induced group), groups 3 and 4 received cadmium solution and different doses of PCA (10 and 20 mg/kg body weight) respectively, while groups 5 and 6 were the normal rats administered different doses of PCA (10 and 20 mg/kg) respectively in an experiment that lasted for twenty one days. The animals were sacrificed, the blood was collected and the serum was subsequently prepared. Furthermore, the liver was excised, homogenized and centrifuged to obtain the tissue homogenate used for the analyses. The serum was used for the determination of the total protein, urea, creatinine and uric acid levels while the liver homogenate was used for the estimation of alanine aminotransferase (ALT), aspartate transaminase (AST), and alkaline phosphatase (ALP). Discussion and evaluation: The result revealed that total protein level was reduced in cadmium induced toxicity rat group which was elevated upon treatment with PCA. Conversely, the elevated levels of urea, uric acid and creatinine in cadmium induced toxicity kidney rats were significantly (p < 0.05) reduced in PCA treated groups. Similarly, marked elevation in the ALT, AST and ALP activity were observed in cadmium induced toxicity rat group when compared with the control group. However, significant (p < 0.05) decrease in ALT, AST and ALP activity were noticed in groups administered different doses of PCA. Conclusions: The results from this study suggest that PCA may protect against cadmium-induced toxicity in the kidney and liver.en_US
dc.identifier.citationAdefegha, S. A., Omojokun, O. S., & Oboh, G. (2015). Modulatory effect of protocatechuic acid on cadmium induced nephrotoxicity and hepatoxicity in rats in vivo. Springerplus, 4(1), 619.en_US
dc.identifier.uri10.1186/s40064-015-1408-6
dc.identifier.urihttp://repository.elizadeuniversity.edu.ng/handle/20.500.12398/652
dc.language.isoenen_US
dc.publisherSpringer International Publishingen_US
dc.subjectCadmiumen_US
dc.subjectHepatotoxicityen_US
dc.subjectNephrotoxicityen_US
dc.subjectProtocatechuic aciden_US
dc.titleModulatory effect of protocatechuic acid on cadmium induced nephrotoxicity and hepatoxicity in rats in vivoen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Modulatory effect of protocatechuic.pdf
Size:
1.08 MB
Format:
Adobe Portable Document Format
Description:
Article full-text
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.61 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Research Articles in Physical and Chemical Sciences