Impact of drying processes on Bryophyllum pinnatum phenolic constituents and its antiinflammatory and antioxidative activities in human erythrocytes

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dc.contributor.authorOmojokun, Olasunkanmi S.
dc.contributor.authorOboh, Ganiyu
dc.contributor.authorAdemiluyi, Adedayo O.
dc.contributor.authorOladele, Josephine O.
dc.contributor.authorBoligon, Aline A.
dc.date.accessioned2021-02-09T14:30:28Z
dc.date.available2021-02-09T14:30:28Z
dc.date.issued2020-06-09
dc.description.abstractThe effect of drying on the phytoconstituents, antioxidative, and anti-inflammatory properties of Bryophyllum pinnatum leaves was investigated. The phenolic constituents were characterized using HPLC-DAD. The aqueous extraction was done and various assays (Inhibition of membrane stabilization, albumin Denaturation and heatinduced hemolysis, malondialdehyde (MDA), and reduced glutathione (GSH) contents, as well as superoxide dismutase (SOD) activity), were carried out on human erythrocytes. The fresh portion (89.12 µg/ml) exhibited the highest potential to inhibit heat-induced hemolysis compared to the standard drug—Diclofenac (91.51 µg/ml). Freeze-dried sample showed the highest inhibitory potential on albumin denaturation ([Freeze-dried-330.72 µg/ml], [Diclofenac-318.63 µg/ml]) and membrane destabilization ([Freeze-dried-331.93 µg/ml], [Diclofenac-289.57 µg/ml]) when compared with Diclofenac. Similarly, the freeze-dried sample showed the highest GSH and SOD level and lowest MDA level when human erythrocytes challenged with tertiary butyl hydroperoxide (tBHP) were treated with the extract. This study confirms the retention of a considerable quantity of bioactive constituents of plants when freeze-dried.en_US
dc.identifier.citationOmojokunOS, Oboh G, Ademiluyi AO, Oladele JO, Boligon AA. Impact of drying processes on Bryophyllum pinnatum phenolic constituents and its antiinflammatory and antioxidative activities in human erythrocytes. J Food Biochem. 2020;00:e13298. https://doi. org/10.1111/jfbc.13298en_US
dc.identifier.urihttps://doi. org/10.1111/jfbc.13298
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/abs/10.1111/jfbc.13298
dc.identifier.urihttp://repository.elizadeuniversity.edu.ng/handle/20.500.12398/834
dc.language.isoenen_US
dc.publisherWileyen_US
dc.subjectAnti-inflammatory,en_US
dc.subjectAntioxidativeen_US
dc.subjectBryophyllum pinnatumen_US
dc.subjectDryingen_US
dc.titleImpact of drying processes on Bryophyllum pinnatum phenolic constituents and its antiinflammatory and antioxidative activities in human erythrocytesen_US
dc.typeArticleen_US
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