Effect of dietary supplementation of Padauk (Pterocarpus soyauxii) leaf on high fat diet/streptozotocin induced diabetes in rats’ brain and platelets

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dc.contributor.authorSaliu, Jamiyu A.
dc.contributor.authorOboh, Ganiyu
dc.contributor.authorOmojokun, Olasunkanmi S.
dc.contributor.authorRocha, João B. T.
dc.contributor.authorSchetinger, Maria R.
dc.contributor.authorGuterries, Jessie
dc.contributor.authorStefanello, Naiara
dc.contributor.authorCarvalho, Fabiano
dc.contributor.authorSchmatz, Roberta
dc.contributor.authorMorsch, Vera M.
dc.contributor.authorBoligon, Aline
dc.date.accessioned2020-01-30T16:11:22Z
dc.date.available2020-01-30T16:11:22Z
dc.date.issued2016-12-01
dc.description.abstractBackground This study investigated the effects of Padauk leaf on brain malondialdehyde (MDA) content, acetylcholinesterase (AChE) activities, ectonucleotidases and adenosine deaminase (ADA) activities in the platelet of high fat diet and streptozotocin (STZ)-induced diabetic rats. Methods The animals were divided into six groups (n = 7): normal control rats; diabetic rats + high fat diet (HFD); diabetic rats + HFD + Metformin; diabetic rats + HFD + acarbose; diabetic rats + HFD + 10% Padauk leaf; normal rats + basal diet + 10% Padauk leaf. After 30 days of experiment comprising of acclimatization, dietary manipulation, pre-treatment with STZ and supplementation with Padauk leaf, the animals were sacrificed and the rats’ brain and blood were collected for subsequent analysis. Results The results demonstrated that the elevated MDA content and AChE activity in the diabetic rats were significantly reduced when compared with the control rats. Furthermore, the increased NTPDases, 5′-nucleotidase and ADA activities in the diabetic rats were significantly reduced when compared with the control rats. Conclusion This study demonstrated that Padauk leaf exhibited modulatory effects on purinergic and cholinergic enzymes involved in the prevention of platelet abnormality and consequent vascular complications in diabetic state.en_US
dc.identifier.citationSaliu, J. A., Oboh, G., Omojokun, O. S., Rocha, J. B., Schetinger, M. R., Guterries, J., ... & Boligon, A. (2016). Effect of dietary supplementation of Padauk (Pterocarpus soyauxii) leaf on high fat diet/streptozotocin induced diabetes in rats’ brain and platelets. Biomedicine & Pharmacotherapy, 84, 1194-1201.en_US
dc.identifier.urihttps://doi.org/10.1016/j.biopha.2016.10.043
dc.identifier.urihttp://repository.elizadeuniversity.edu.ng/handle/20.500.12398/653
dc.language.isoenen_US
dc.publisherElsevier Massonen_US
dc.subjectPadauk leafen_US
dc.subjectDiabetes mellitusen_US
dc.subjectCholinesterasesen_US
dc.subjectEctonucleotidasesen_US
dc.subjectAdenosine deaminaseen_US
dc.titleEffect of dietary supplementation of Padauk (Pterocarpus soyauxii) leaf on high fat diet/streptozotocin induced diabetes in rats’ brain and plateletsen_US
dc.typeArticleen_US
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