Acute Toxicity and Lethality of Gladiolous psittacinus

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dc.contributor.authorMoshood, Abdullah Ishaq
dc.contributor.authorOla-Mudathir, Fausat Kikelomo
dc.contributor.authorEfere, Martins Obuotor
dc.contributor.authorAbdulrahim, Marufat Iyaboale
dc.contributor.authorWasiu, Idris Adegbite
dc.date.accessioned2021-02-17T11:53:52Z
dc.date.available2021-02-17T11:53:52Z
dc.date.issued2017-04-30
dc.descriptionStaff Publicationen_US
dc.description.abstractThe use of Gladiolouspsittacinusplant in traditional medicine is drastically increasing across the country Nigeria. This study was therefore conducted to evaluate the safety level of G. psittacinus using acute toxicity test (determination of median Lethal Dose; LD50) and the Brine shrimp lethality assay (BSLA). Histopathological analysis of the liver of rats orally administered with different dosages of G. psittacinus (1600, 2800 and 5000 mg/kg body weight) was also conducted. Results revealed amedian lethal dose (LD50) of the aqueous extract of G. psitticanus as 2116.60 mg/kg body weight. Similarly, the lethality concentration (LC50) of methanolic extract of G. psitticanus (16.950μg/ml) was higher than the test standard, K2Cr2O7 (5.653 μg/ml). The degree of lethality was also observed to be directly proportional to the concentration of the extracts. Histological studies also revealed that oral administration of G. psittacinus at 1600, 2800 and 5000 mg/kg body weight has the potential to cause some damages on the liver cells. Although G. psittacinus is a potential ethnomedicinal plant, its oral consumption is slightly toxic.en_US
dc.identifier.citationIshaq, M.A., Kikelomo, O., Obuotor, E.M., Iyaboale, A., & Wasiu, I.A. (2017). Acute Toxicity and Lethality of Gladiolous psittacinus. IOSR Journal of Pharmacy and Biological Sciences, 12, 71-75. DOI:10.9790/3008-1202037175en_US
dc.identifier.issn2278-3008
dc.identifier.uriDOI:10.9790/3008-1202037175
dc.identifier.urihttp://repository.elizadeuniversity.edu.ng/handle/20.500.12398/873
dc.language.isoenen_US
dc.publisherIOSR Journal of Pharmacy and Biological Sciencesen_US
dc.subjectGladiolous psittacinus,en_US
dc.subjectbrine shrimp,en_US
dc.subjecttoxicity,en_US
dc.subjectmedicinal plant,en_US
dc.subjectLD50,en_US
dc.subjectoral doseen_US
dc.titleAcute Toxicity and Lethality of Gladiolous psittacinusen_US
dc.typeArticleen_US
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