Browsing by Author "Ofusori, David A."

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    BIOCHEMICAL CHANGES IN STREPTOZOTOCIN-INDUCED DIABETIC RATS AFTER TREATMENT WITH ETHANOLIC LEAF EXTRACT OF Croton Zambesicus (Müll. Arg.)
    (Journal of International Research in Medical and Pharmaceutical Sciences, 2016-02-18) Ofusori, David A.; Komolafe, Omobola A.; Adewole, Olarinde S.; Abiodun, Adeleke A.; Ayoka, Abiodun O.; Fakunle, Julius B.
    Objective: This study was designed to evaluate the effect of ethanolic leaf extract of C. zambesicus on total protein (TP), albumin (ALB), globulin (GLO), lactate dehydrogenase (LDH) and glucose-6-phosphate dehydrogenase (G6PDH) in streptozotocin (STZ) induced diabetic rats. Methods: Seventy adult male wistar rats were divided into seven groups (n=10). Group A, control rats; Group B, untreated diabetic rats; Group C, diabetic rats in which C. zambesicus therapy started 2 weeks prior to induction of diabetes; Group D, diabetic rats administered orally with C. zambesicus leafextract for 2 weeks after the initial four weeks of diabetic induction; Group E, diabetic rats administered orally with C. zambesicus leaf extract for 4 weeks after the initial four weeks of diabetic induction; Group F, normal rats administered orally with C. zambesicus leaf extract for four weeks; Group G, diabetic rats administered with glimepiride (2 mg/kg/day) for four weeks after the initial four weeks of diabetic induction. At the end of the experimental period, the animals were weighed and sacrificed. Serum was obtained for TP, ALB, LDH and G6PDH analysis using respective diagnostic kits. Results: The results showed an improvement in protein metaboloites (TP, ALB, GLO) whiles the LDH and G6PDH in the extract and glimepiride treated groups were restored near normal level when compared with normal control (group A). Conclusion: In conclusion, this study showed that C. zambesicus leaf extract exerts positive effects on serum levels of TP, ALB, GLO, LDH and G6PDH in diabetic rats. Thus, ethanolic leaf extract of Croton zambesicus can be adopted in the management of diabetes mellitus.
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    Effect of ethanolic leaf extract of Croton zambesicus (Müll. Arg.) on lipid profile in streptozotocin-induced diabetic rats
    (Diabetol Croat, 2012-09) Ofusori, David A.; Komolafe, Omobola A.; Adewole, Olarinde S.; Obuotor, Efere M.; Fakunle, Julius B.; Ayoka, Abiodun O.
    Croton zambesicus (C. zambesicus) leaves have recently been identified as an antidiabetic agent in Africa. The aim of this study was to examine the effect of C. zambesicus leaf extract on lipid profile in experimentally induced diabetic rats. Seventy adult male Wistar rats were divided into seven groups (n=10): group A, control rats; group B, untreated diabetic rats; group C, diabetic rats in which C. zambesicus therapy started 2 weeks prior to induction of diabetes; group D, diabetic rats administered orally with C. zambesicus leaf extract for 2 weeks after the initial four weeks of diabetes induction; group E, diabetic rats administered orally with C. zambesicus leaf extract for 4 weeks after the initial four weeks of diabetes induction; group F, normal rats administered orally with C. zambesicus leaf extract for four weeks; and group G, diabetic rats administered with glimepiride (2 mg/kg/day) for four weeks after the initial four weeks of diabetes induction. At the end of the experimental period, the animals were weighed and sacrificed. Serum was obtained for lipid profile analysis using respective diagnostic kits. The results showed that the blood glucose level and body weights of extract and glimepiride treated groups were restored to the near normal level. The triglyceride, total cholesterol, low density lipoprotein and very low density lipoprotein cholesterol levels were increased significantly (P Key words: diabetes, lipid profile, Croton zambesicus, glimepiride, streptozotocin